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Wednesday, May 31st, 2023 8:20 PM

Defacing your mental chemistry map

Derek Lowe has written a nice piece Amines Learn to Join the Fun drawing our attention to a paper “Direct Deaminative Functionalization.” 

In his post, Lowe claims “My mental map of standard organic chemistry transformations keeps getting defaced, and I’m glad of it. 

One of the key pillars of science is the ability to re-draw the map when new evidence is presented. In fact, Willard van Orman Quine wrote a whole book about it, no less (The Web of Belief, if you’re interested). 

Derek Lowe comments, “The paper demonstrates a long list of interesting transformations on primary and secondary aliphatic amines, aromatic amines, and heteroaryl ones as well. And I definitely appreciate the inclusion of numerous things that didn’t work, with likely reasons why they failed. 

The blog post: http://ms.spr.ly/61219guPth  

The original paper: http://ms.spr.ly/61210guPQ6 

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